WebDrug files were created for (S)- and (R)-fluoxetine and for (S)- and (R)-norfluoxtine as metabolites of fluoxetine with the drug specific parameters (Table 2). The recombinant enzyme intrinsic clearance values were calculated in Simcyp from the in vivo oral CL in CYP2D6 extensive metabolizers and the CYP2D6 f m of 0.98 based on EM versus PM ... WebDrugs Tightly Bound to Plasma Proteins — Because fluoxetine is tightly bound to plasma proteins, the administration of fluoxetine to a patient taking another drug that is tightly bound to protein (e.g., Coumadin, digitoxin) may cause a shift in plasma concentrations potentially resulting in an adverse effect [see CLINICAL PHARMACOLOGY (12.3)].
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ACOG Guidelines on Psychiatric Medication Use During Pregnancy …
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